Is administration of preoperative angiotensin-converting enzyme inhibitors important for renal protection after cardiac surgery?
| Autor: | Mehmet Ali Kaygin, Nail Kahraman, Ozgur Dag, Ümit Arslan, Eyup Serhat Calik, Bilgehan Erkut, Adem Kiymaz, Ahmet Aydin, Hüsnü Kamil Limandal |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Renal function Angiotensin-Converting Enzyme Inhibitors Critical Care and Intensive Care Medicine law.invention Renin-Angiotensin System chemistry.chemical_compound Postoperative Complications Ramipril law Internal medicine Preoperative Care Cardiopulmonary bypass medicine Humans Renal Insufficiency Cardiac Surgical Procedures Blood urea nitrogen Dialysis Aged Retrospective Studies Creatinine biology business.industry Angiotensin-converting enzyme General Medicine Middle Aged Cardiac surgery Logistic Models chemistry Nephrology ACE inhibitor biology.protein Cardiology Female business medicine.drug |
| Zdroj: | Renal failure. 35(5) |
| ISSN: | 1525-6049 |
| Popis: | There are various reasons for renal dysfunction after cardiac surgery; however, activation of the renin-angiotensin system has an important role following cardiac surgery. We investigated the effect of preoperative angiotensin-converting enzyme (ACE) inhibitors on renal functions after cardiovascular surgery.Three hundred sixty-six patients awaiting elective cardiac surgery were allocated to two groups, namely the treatment group, comprising the ACE inhibitor group (n = 186), and the control group, which was without ACE inhibitor (n = 180). The renal parameters [blood urea nitrogen, creatinine, creatinine clearance, and glomerular filtration rate (GFR)] and the need for dialysis were evaluated associated with renal functions between the two groups in the postoperative period.After cardiac surgery, renal dysfunction requiring dialysis developed in 11 (3.8%) patients in the control group patients. There was no required dialysis in the treatment group (p0.05). As an indicator of renal dysfunction, the increase in creatinine and blood urea nitrogen levels and the decrease in GFR and creatinine clearance were higher in the control group (p0.05). The multivariate analysis indicated that therapy with ACE inhibitors was found to decrease the incidence of postoperative renal dysfunction (odds ratio, 1.07; 95% confidence interval, 0.45-2.50; p0.05). The other independent predictors were age, preoperative intra-aortic blood pump, hypertension, diabetes mellitus, and a left ventricular ejection fraction below 0.40.Preoperative therapy with ACE inhibitors has an influence on renal functions. This study demonstrates that administration of ACE inhibitors provides better renal protection after cardiac surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |