Recent Advances in the Biosynthesis of Farnesene Using Metabolic Engineering

Autor:	Ruohao Tang, Qifeng Wen, Meijie Li, Wei Zhang, Zhaobao Wang, Jianming Yang
Rok vydání:	2021
Předmět:	Metabolic Engineering Acetyl Coenzyme A Terpenes General Chemistry General Agricultural and Biological Sciences Sesquiterpenes Metabolic Networks and Pathways
Zdroj:	Journal of Agricultural and Food Chemistry. 69:15468-15483
ISSN:	1520-5118 0021-8561
Popis:	Farnesene, as an important sesquiterpene isoprenoid polymer of acetyl-CoA, is a renewable feedstock for diesel fuel, polymers, and cosmetics. It has been widely applied in agriculture, medicine, energy, and other fields. In recent years, farnesene biosynthesis is considered a green and economical approach because of its mild reaction conditions, low environmental pollution, and sustainability. Metabolic engineering has been widely applied to construct cell factories for farnesene biosynthesis. In this paper, the research progress, common problems, and strategies of farnesene biosynthesis are reviewed. They are mainly described from the perspectives of the current status of farnesene biosynthesis in different host cells, optimization of the metabolic pathway for farnesene biosynthesis, and key enzymes for farnesene biosynthesis. Furthermore, the challenges and prospects for future farnesene biosynthesis are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a1b4f6a0e1d43c2df32c0467b0e142 https://doi.org/10.1021/acs.jafc.1c06022 Zobrazit plný text záznamu