Microbial Modulation of the Development and Physiology of the Enteric Nervous System
| Autor: | François Leulier, Filipe De Vadder, Amélie Joly |
|---|---|
| Přispěvatelé: | Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), ANR-18-CE15-0011,SymEnvLop,Symbiose bénéfique hôte-microbiote durant une sous nutrition chronique: Enveloppe bactérienne et promotion de la croissance linéaire(2018) |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Fluid homeostasis [SDV]Life Sciences [q-bio] Intestinal physiology Motility Physiology Enteroendocrine cell Gut flora digestive system Microbiology 03 medical and health sciences enteric nervous system Immune system Virology microbiota Homeostasis Humans 030304 developmental biology Neurons 0303 health sciences Gastrointestinal tract enteroendocrine cells biology 030306 microbiology intestinal physiology Gene Expression Regulation Bacterial biology.organism_classification Gastrointestinal Microbiome Intestines Infectious Diseases Enteric nervous system intestinal immune system |
| Zdroj: | Trends in Microbiology Trends in Microbiology, Elsevier, 2021, 29 (8), pp.686-699. ⟨10.1016/j.tim.2020.11.007⟩ Trends in Microbiology, 2021, 29 (8), pp.686-699. ⟨10.1016/j.tim.2020.11.007⟩ |
| ISSN: | 0966-842X |
| Popis: | International audience; The gastrointestinal tract harbors an intrinsic neuronal network, the enteric nervous system (ENS). The ENS controls motility, fluid homeostasis and blood flow, but also interacts with other components of the intestine such as epithelial and immune cells. Recent studies indicate that gut microbiota diversification occurring concomitantly to postnatal ENS maturation could be critical for ENS development and function. Here we discuss the possibility that this functional relationship starts in utero, whereby the maternal microbiota would prime the developing ENS and shape its physiology. We review the ENS/microbiota interactions and their modulation in physiological and pathophysiological contexts. While the microbial modulation of ENS physiology is now well established, further studies are required to understand the contribution of the gut microbiota to the ENS development and pathologies and to reveal the precise mechanisms underlying microbiota-to-ENS communications. |
| Databáze: | OpenAIRE |
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