Effects of intravenous SM-9527 (double-chain tissue plasminogen activator) on left ventricular function in the chronic stage of acute myocardial infarction
| Autor: | Hiroshi Hayashi, Junichi Osugi, Kazunobu Yamauchi, Noboru Mizutani, Hirokazu Ogawa, Haruo Hirayama, Tsutomu Watanabe, Kazuo Yamada, Fumimaro Takatsu, Hidehiko Saito, Takahito Sone |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Tissue plasminogen activator Ventricular Function Left Double chain Internal medicine Fibrinolysis medicine Thrombolytic Agent Humans Thrombolytic Therapy Myocardial infarction Adverse effect Infusions Intravenous Aged Chronic stage Chemotherapy business.industry Stroke Volume General Medicine Middle Aged medicine.disease Coronary Vessels Myocardial Contraction Survival Rate Tissue Plasminogen Activator Chronic Disease Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Clinical cardiology. 16(5) |
| ISSN: | 0160-9289 |
| Popis: | Clinical effects of thrombolytic agent SM-9527 (double-chain tissue plasminogen activator) on left ventricular (LV) function were assessed in patients with acute myocardial infarction (AMI). A dose of 30 x 10(6) IU SM-9527 was given intravenously to patients with AMI within 6 h after onset. Of 159 candidates, 20 were excluded from the trial due to diseases other than myocardial infarction or failure to meet the protocol requirements; 114 of the remaining 139 were subjected to LV function analysis. The following results were obtained: (1) Patients with successful reperfusion in response to SM-9527 in the acute stage without later reocclusion revealed a significant improvement of LV function in the chronic stage. (2) Adverse effects were noted in 15 patients (10.8%), but none were serious; all were bleeding related to catheterization. (3) Hemagglutination fibrinolysis system test revealed no problems. It is concluded that early thrombolytic therapy with intravenous SM-9527 for AMI provides significant improvement of LV function in the chronic stage. |
| Databáze: | OpenAIRE |
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