Relationship between videofluoroscopic and subjective (physician- and patient- rated) assessment of late swallowing dysfunction after (chemo) radiation: Results of a prospective observational study
| Autor: | Hans Paul van der Laan, Rico N Rinkel, Johannes A. Langendijk, Nathalie Perdok, Irma M. Verdonck-de Leeuw, A. Gawryszuk, Hendrik P. Bijl, Jan Wedman, Johanna G M van den Hoek, Arjen van der Schaaf, Roel J H M Steenbakkers |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), CCA - Cancer Treatment and quality of life, APH - Personalized Medicine, APH - Mental Health, Otolaryngology / Head & Neck Surgery, CCA - Imaging and biomarkers |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
EUROPEAN-ORGANIZATION ASPIRATION THERAPY TOXICITY Videofluoroscopy Swallowing NECK-CANCER QUALITY-OF-LIFE Physicians Internal medicine medicine otorhinolaryngologic diseases Humans Radiology Nuclear Medicine and imaging Prospective Studies HEAD Stage (cooking) Pharyngeal Residue Head and neck cancer business.industry INTENSITY Swallowing Disorders (Chemo)radiation Hematology Dysphagia medicine.disease Deglutition Oncology Quality of Life Observational study medicine.symptom Deglutition Disorders Choking business RADIOTHERAPY |
| Zdroj: | Radiotherapy and Oncology, 164, 253-260. ELSEVIER IRELAND LTD Radiotherapy and Oncology, 164, 253-260. Elsevier Ireland Ltd Gawryszuk, A, Bijl, H P, van der Schaaf, A, Perdok, N, Wedman, J, Verdonck-de Leeuw, I M, Rinkel, R N, Steenbakkers, R J H M, van den Hoek, J G M, van der Laan, H P & Langendijk, J A 2021, ' Relationship between videofluoroscopic and subjective (physician-and patient-rated) assessment of late swallowing dysfunction after (chemo) radiation : Results of a prospective observational study ', Radiotherapy and Oncology, vol. 164, pp. 253-260 . https://doi.org/10.1016/j.radonc.2021.09.017 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2021.09.017 |
| Popis: | BACKGROUND AND PURPOSE: Primary (chemo)radiation (CHRT) for HNC may lead to late dysphagia. The purpose of this study was to assess the pattern of swallowing disorders based on prospectively collected objective videofluoroscopic (VF) assessment and to assess the correlations between VF findings and subjective (physician- and patient-rated) swallowing measures.MATERIAL AND METHODS: 189 consecutive HNC patients receiving (CH)RT were included. Swallowing evaluation at baseline and 6 months after treatment (T6) encompassed: CTCAE v.4.0 scores (aspiration/dysphagia), PROMs: SWAL QOL/ EORTC QLQ-H&N35 (swallowing domain) questionnaires and VF evaluation: Penetration Aspiration Scale, semi-quantitative swallowing pathophysiology evaluation, temporal measures and oral/pharyngeal residue quantification. Aspiration specific PROMs (aPROMs) were selected. Correlations between late penetration/aspiration (PA_T6) and: clinical factors, CTCAE and aPROMs were assessed using uni- and multivariable analysis.RESULTS: Prevalence of PA increased from 20% at baseline to 43% after treatment (pCONCLUSION: The risk of RT-induced PA is substantial. Presented prediction models for late penetration/aspiration may support patient selection for baseline and follow-up VF examination. Furthermore, all aspiration related OARs involved in aforementioned swallowing components should be addressed in swallowing sparing strategies. The dose to these structures as well as baseline PROMs should be included in future NTCP models for aspiration. |
| Databáze: | OpenAIRE |
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