Diastereocontrolled Construction of Pactamycin’s Complex Ureido Triol Functional Array
| Autor: | Stefan J. McCarver, Justin T. Malinowski, Jeffrey S. Johnson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Methylurea Compounds Antibiotics Antineoplastic Ketone Molecular Structure Pactamycin Stereochemistry Organic Chemistry Stereoisomerism Ketones Biochemistry Catalysis Article Stereocenter chemistry.chemical_compound Nucleophile chemistry Triol Physical and Theoretical Chemistry |
| DOI: | 10.17615/rybh-t478 |
| Popis: | An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelation-controlled addition of organometal nucleophiles to the C5 prochiral ketone. Four of the molecule's six stereocenters are set with a ketone functional handle provided for subsequent manipulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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