Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium
| Autor: | Viktor Oskarsson, Mats Eliasson, Veikko Salomaa, Jaakko Reinikainen, Satu Männistö, Luigi Palmieri, Chiara Donfrancesco, Susana Sans, Simona Costanzo, Giovanni de Gaetano, Licia Iacoviello, Giovanni Veronesi, Marco M. Ferrario, Teresa Padro, Barbara Thorand, Cornelia Huth, Tanja Zeller, Stefan Blankenberg, Annie S. Anderson, Hugh Tunstall-Pedoe, Kari Kuulasmaa, Stefan Söderberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | BRITISH JOURNAL OF NUTRITION r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Br. J. Nutr. 128, 2208–2218 (2022) |
| ISSN: | 0007-1145 |
| Popis: | Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48 center dot 9 %; median age 50 center dot 8 years; examination period 1984-2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65 center dot 6-63 center dot 8 degrees N), Germany (at 48 center dot 4 degrees N), Finland (at 65 center dot 0-60 center dot 2 degrees N), Italy (at 45 center dot 6-41 center dot 5 degrees N), Scotland (at 58 center dot 2-55 center dot 1 degrees N) and Spain (at 41 center dot 5 degrees N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3 center dot 03, 3 center dot 28, 5 center dot 41, 6 center dot 54 and 9 center dot 28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0 center dot 001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans. |
| Databáze: | OpenAIRE |
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