Establishment of a Model of Spontaneously-Running-Tokushima-Shikoku Rats with Left Atrial Thrombosis
| Autor: | Yutaka Nakaya, Akira Takahashi, Emiko Yoshioka, Kazuaki Mawatari, Hidekazu Arai, Satomi Toda, Fumiko Hisaoka, Keisuke Izumi, Masaki Morishima, Nagakatsu Harada, Takamasa Ohnishi |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry Treatment options Atrial fibrillation heart Toxicology medicine.disease Atrial thrombosis Thrombosis Pathology and Forensic Medicine Surgery atrial thrombosis Animal model Left atrial Internal medicine Antithrombotic Male rats cardiovascular system medicine Cardiology Original Article rat cardiovascular diseases business |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.2012-0032 |
| Popis: | Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat — a Wistar strain known for its running ability—is predisposed to the development of thrombi in the left atrium. We investigated the incidence of left atrial thrombosis in male (n = 16) and female (n = 17) SPORTS rats and observed organized atrial thrombosis in 57% and 38% of males and female rats, respectively. In the male rats, systolic blood pressures and heart rates were significantly higher in SPORTS rats than in control Wistar rats. We could not find any evidence of arrhythmias, such as atrial fibrillation, during electrocardiographic examination of SPORTS rats. We believe that the SPORTS rat could serve as a new research model for left atrial thrombosis; further, it may be suitable for research investigating the development of new antithrombotic approaches for the control of atrial thrombosis or familial thrombophilia in humans. |
| Databáze: | OpenAIRE |
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