Canine non‐epitheliotropic CD4‐positive cutaneous T‐cell lymphoma: a case report
| Autor: | Kinji Shirota, Hitoshi Kondo, Peter F Moore, Masahiko Nagata, Yumiko Kagawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty cutaneous T‐cell lymphoma 040301 veterinary sciences CD3 biology.animal_breed Case Report French bulldog 0403 veterinary science 03 medical and health sciences Dermis medicine CD90 CD20 integumentary system General Veterinary biology business.industry Cutaneous T-cell lymphoma 04 agricultural and veterinary sciences medicine.disease 030104 developmental biology medicine.anatomical_structure dog biology.protein Immunohistochemistry business Infiltration (medical) CD4 positive cells |
| Zdroj: | Veterinary Medicine and Science |
| ISSN: | 2053-1095 |
| Popis: | A 5‐year‐old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC‐II, and TCRγδ. In addition, CD45 was highly expressed, and the proliferation fraction was very low. Molecular clonality of T‐cell receptor G chains yielded a clonal result. The skin lesions were surgically excised because they had progressed to the lateral front leg. Postoperative clinical course was favorable, and recurrence was not observed until the dog died in a traffic accident, approximately 1 year later. |
| Databáze: | OpenAIRE |
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