Evidence for the involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice
| Autor: | Ana Lúcia S. Rodrigues, Nelson H. Gabilan, Rúbia C. Almeida, Manuela G. López, Cristiane S. Felisbino |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Arginine Nitric Oxide Nitroarginine Piperazines Sildenafil Citrate Nitric oxide Mice Behavioral Neuroscience chemistry.chemical_compound Memantine Internal medicine medicine Animals Drug Interactions Nitric Oxide Donors Sulfones Enzyme Inhibitors Cyclic GMP Cyclic guanosine monophosphate Swimming Analysis of Variance Dose-Response Relationship Drug Depression Penicillamine Glutamate receptor Antagonist Immobility Response Tonic Antidepressive Agents Disease Models Animal Endocrinology chemistry Purines NMDA receptor Female medicine.drug |
| Zdroj: | Behavioural Brain Research. 168:318-322 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2005.11.023 |
| Popis: | This study investigated the involvement of the L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the antidepressant-like effect of an acute administration of memantine in the forced swimming test (FST) in mice, since this signaling pathway is supposed to play a significant role in depression. The antidepressant-like effect of memantine (3 mg/kg, i.p.) was prevented by pretreatment with L-arginine (750 mg/kg, i.p.) or S-nitroso-N-acetyl-penicillamine (SNAP, 25 microg/site, i.c.v.), but not with d-arginine (750 mg/kg, i.p.).The treatment of mice with NG-nitro-L-arginine (L-NNA, 0.03 and 0.3 mg/kg, i.p.) potentiated the effect of a subeffective dose of memantine (0.3 mg/kg, i.p.) in the FST. Moreover, the pretreatment of mice with (1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one) (ODQ, 30 pmol/site, i.c.v.) produced a synergistic antidepressant-like effect with subeffective doses of memantine (0.3 and 1 mg/kg, i.p.) in the FST. Furthermore, the reduction in the immobility time elicited by memantine (3 mg/kg, i.p.) in the FST was prevented by pretreatment with sildenafil (5 mg/kg, i.p.). Taken together, the results demonstrate that memantine produced an antidepressant-like effect in the FST that seems to be mediated through an interaction with the L-arginine-NO-cGMP pathway. |
| Databáze: | OpenAIRE |
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