Glycated albumin is independently associated with estimated glomerular filtration rate in nondiabetic patients with chronic kidney disease
| Autor: | Yi Min Chu, Ching-Chieh Su, Kuo-Cheng Lu, Kuo-Chin Hung, Chia-Chao Wu, Te-Lin Hsia, Wen-Ya Ma, Dee Pei |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Glycosylation medicine.medical_treatment Clinical Biochemistry Serum albumin Urology Renal function Biochemistry Diabetic nephropathy Diabetes mellitus medicine Humans Clinical significance Stage (cooking) Renal Insufficiency Chronic Dialysis Serum Albumin biology business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease biology.protein Female business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 412(7-8) |
| ISSN: | 1873-3492 |
| Popis: | Glycated albumin (GA) may contribute to diabetic nephropathy, but the clinical significance of GA in patients with chronic kidney disease (CKD) is unknown.Patients were classified with the NKF/DOQI classification system as mild (stage I, II), moderate (stage III), or advanced CKD (stage IV). Those undergoing dialysis or with CKD stage V were excluded. GA was measured using the Lucica TM GA-L assay kit. The relationship between GA and renal dysfunction was analyzed in patients with or without diabetes.A total of 187 subjects were enrolled. GA values in those with normal, mild, moderate and advanced CKD were 18.4 ± 1.4%, 18.4 ± 3.1%, 19.0 ± 3.8%, 20.4 ± 6.4%, respectively, in diabetic patients (N=67, p=0.5), and were 14.1 ± 1.9%, 14.2 ± 2.2%, 15.9 ± 1.9%, 15.0 ± 1.7%, respectively, in nondiabetic patients (N=120, p=0.004). GA value was negatively correlated to eGFR in nondiabetic patients (r=-0.35, p0.001) but not in diabetic patients (r=-0.11, p=0.39). In the adjusted model, GA is independently correlated to eGFR only in nondiabetic subjects.Increased GA concentrations are independently associated with renal dysfunction in nondiabetic patients with CKD. |
| Databáze: | OpenAIRE |
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