Synthesis of analogs and oligomers of N-(2-aminoethyl)glycine and their gastrointestinal absorption in the rat
| Autor: | F. Scheidl, Edgar P. Heimer, Johannes Meienhofer, Hugo E. Gallo-Torres, Mushtaq Ahmad, Theodore Lambros, Arthur Felix |
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| Rok vydání: | 1984 |
| Předmět: |
Absorption (pharmacology)
Oligopeptide Tetrapeptide Stereochemistry Substituent Glycine Biological activity Biochemistry Intestinal absorption Rats chemistry.chemical_compound Kinetics Structure-Activity Relationship chemistry Intestinal Absorption Structure–activity relationship Animals Female Indicators and Reagents |
| Zdroj: | International journal of peptide and protein research. 23(2) |
| ISSN: | 0367-8377 |
| Popis: | The synthesis of a series of analogs and oligomers of N-(2-aminoethyl)glycine (Aeg) are described. The gastrointestinal absorption of these compounds was determined after intragastric administration. Analogs of Aeg bearing a substituent at the amino or carboxyl functions were absorbed to a lesser extent than the parent compound. In contrast, the di- and tetra-oligomers of Aeg were more rapidly absorbed. Total absorption of these compounds was observed within 2 h after intragastric administration. |
| Databáze: | OpenAIRE |
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