Polymer–drug conjugates: recent advances and future perspectives
| Autor: | Neelesh Kumar Mehra, Shashi Bala Singh, Saurabh Srivastava, Valamla Bhavana, Pradip Thakor, Reena Sharma |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology Drug chemistry.chemical_classification Drug Carriers Polymer-drug conjugates Polymers Chemistry media_common.quotation_subject hemic and immune systems Nanotechnology Polymer Ligands 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Pharmaceutical Preparations 030220 oncology & carcinogenesis Drug Discovery Drug delivery Animals Humans Computer Simulation Linker media_common |
| Zdroj: | Drug Discovery Today. 25:1718-1726 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2020.06.028 |
| Popis: | Polymer-drug conjugates (PDC) have exhibited clinical and commercial success in the field of drug delivery. A polymeric backbone, linker, targeting moiety, and drug constitute the building blocks of PDCs. Current attention is focusing on natural polymeric carriers, in particular the concept of graft copolymers, such as a combination of polymers and polysaccharides, to explore dual benefits such as combined vehicles and targeting moieties. Polymer heterogeneity, synthesis of PDCs, broad molecular weight distribution, conjugate variability, immunogenicity of polymers, safety, stability, and stringent regulatory approval are the major obstacles to the successful transition of PDCs to the clinic. In this review, we discuss natural and synthetic PDCs combined with computational modeling for diverse pharmaceutical and biomedical applications. |
| Databáze: | OpenAIRE |
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