Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
| Autor: | Glenda M. Halliday, Neil Manwaring, Dominic B. Rowe, Paul Mitchell, George D. Mellick, Himesha Vandebona, Peter A. Silburn, Prachi Mehta, Carolyn M. Sue, Jie Jin Wang, Michael M. Jones |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Risk Mitochondrial DNA medicine.medical_specialty genetic structures Population Lower risk Gastroenterology DNA Mitochondrial Polymorphism Single Nucleotide Haplogroup White People Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease Age of Onset education Aged Aged 80 and over education.field_of_study business.industry Haplotype Australia Parkinson Disease social sciences Middle Aged eye diseases humanities Europe Neurology Haplotypes Case-Control Studies Female Neurology (clinical) Restriction fragment length polymorphism business geographic locations Human mitochondrial DNA haplogroup |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 24(2) |
| ISSN: | 1531-8257 |
| Popis: | MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text