Anti-inflammatory properties of [i]Streptococcus salivarius[/i], a commensal bacterium of the oral cavity and digestive tract
| Autor: | Bruno Pot, Ghalia Kaci, Hervé M. Blottière, Pierre Renault, Véronique Dennin, Catherine Daniel, Joël Doré, Christine Delorme, S. Dusko Ehrlich, Denise Goudercourt |
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| Přispěvatelé: | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre d’Infection et d’Immunité de Lille (CIIL) - U1019 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique, European Project: 201052, Department of Bio-engineering Sciences, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Archive Ouverte, Metagenomics of the Human Intestinal Tract - 201052 - INCOMING |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
mice
medicine.drug_class [SDV]Life Sciences [q-bio] Anti-Inflammatory Agents Inflammation Biology Applied Microbiology and Biotechnology Peripheral blood mononuclear cell Anti-inflammatory Microbiology stomatognathic system In vivo Gastrointestinal Tract/microbiology medicine Animals Humans Colitis/immunology Colitis Leukocytes Mononuclear/immunology Mouth Ecology anti-inflammatoire Epithelial Cells/immunology NF-kappa B Streptococcus Epithelial Cells NF-kappa B/antagonists & inhibitors biology.organism_classification medicine.disease Anti-Inflammatory Agents/metabolism In vitro symbiosis 3. Good health [SDV] Life Sciences [q-bio] Gastrointestinal Tract Disease Models Animal stomatognathic diseases Streptococcus salivarius Immunology Leukocytes Mononuclear Food Microbiology Mouth/microbiology Streptococcus/immunology medicine.symptom streptococcus salivarius Bacteria Food Science Biotechnology |
| Zdroj: | Applied and Environmental Microbiology Applied and Environmental Microbiology, American Society for Microbiology, 2014, 80 (3), pp.928-934. ⟨10.1128/AEM.03133-13⟩ Applied and Environmental Microbiology, 2014, 80 (3), pp.928-934. ⟨10.1128/AEM.03133-13⟩ Applied and Environmental Microbiology 3 (80), 928-934. (2014) |
| ISSN: | 0099-2240 1098-5336 |
| Popis: | Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius , suggesting a protective response exclusively with metabolically active bacteria. |
| Databáze: | OpenAIRE |
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