Neuropeptides and ATP signaling in the trigeminal ganglion

Autor: Haruki Iwai, Atsushi Yamanaka, Eriko Kuramoto, Tetsuya Goto
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_specialty
Neuropeptide
Review Article
VIP
vasoactive intestinal peptide
ATP
adenosine 3′-phosphate
PACAP
pituitary adenylate-cyclase-activating polypeptide receptor type 1
Calcitonin gene-related peptide
Biology
03 medical and health sciences
Trigeminal ganglion
0302 clinical medicine
Dorsal root ganglion
VNUT
vesicular nucleotide transporter
Internal medicine
medicine
CGRP
calcitonin-gene-related peptide
General Dentistry
SP
substance P
MLC
microglia/macrophage-like cell
Trigeminal nerve
Satellite glial cell
Dentistry(all)
Neuropeptides
Neuron
DRG
dorsal root ganglion
Cell biology
TG
trigeminal ganglion
ATP
lcsh:RK1-715
030104 developmental biology
Allodynia
Endocrinology
medicine.anatomical_structure
nervous system
lcsh:Dentistry
medicine.symptom
SGC
satellite glial cell
030217 neurology & neurosurgery
Zdroj: Japanese Dental Science Review, Vol 53, Iss 4, Pp 117-124 (2017)
The Japanese Dental Science Review
ISSN: 1882-7616
DOI: 10.1016/j.jdsr.2017.01.003
Popis: Summary Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite glial cells (SGCs), which initially receive the signal from TG neurons. These activated SGCs secrete a transmitter to activate adjacent SGCs or TG neurons, thereby amplifying the signal, for example, from mandibular neurons to maxillary neurons in the TG. Similar to the dorsal root ganglion, in the TG, microglia/macrophage-like cells (MLCs) are activated by uptake of a transmitter from TG neurons or SGCs. This communication between neurons, SGCs, and MLCs results in responses such as ectopic pain, hyperesthesia, or allodynia. The focus of this review is the cooperative interaction of the maxillary and mandibular nerves in the TG by neuropeptides, and adenosine 3′-phosphate (ATP) signaling from neurons to SGCs and MLCs. Stimulated neurons either secrete ATP by means of vesicular nucleotide transporters, or secrete neuropeptides from the neuronal cell body to mediate signal transmission.
Databáze: OpenAIRE
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