Impact of asphyxia on red blood cell folate concentration levels in newborns
| Autor: | Revakova T, Dubovicky M, Eduard Ujházy, Mach M, Ingrid Brucknerová, A Vasilenkova |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Economics and Econometrics Erythrocytes medicine.medical_treatment Physiology Gestational Age Folic Acid Sex Factors Materials Chemistry Media Technology medicine Humans Caesarean section Prospective Studies Prospective cohort study Asphyxia Asphyxia Neonatorum business.industry Infant Newborn Gestational age Forestry Fetal Blood medicine.disease Perinatal asphyxia Red Blood Cell Folate Red blood cell medicine.anatomical_structure Anesthesia Female medicine.symptom business |
| Zdroj: | Bratislava Medical Journal. 116:417-421 |
| ISSN: | 1336-0345 |
| Popis: | OBJECTIVES To determine whether red blood cell (RBC) folate concentration levels are correlated with the occurrence of neonatal asphyxia and to study the effects of gestational age, gender, and mode of delivery on RBC folate concentration levels in newborns. BACKGROUND Asphyxia is one of the frequent causes of morbidity and mortality of newborns. Severe perinatal asphyxia can arise due to many factors. METHODS In a prospective study, the RBC folate concentrations were determined on day 1 of life in the whole group (n=181) of full-term (n=121) and preterm (n=60) newborns. Immunochemical analysis for the determination of folate in erythrocytes was performed. RESULTS RBC folate concentration levels in asphyxiated newborns (n=16) were significantly decreased (median 974 ng/ml; p=0.023) in comparison with healthy newborns. On the other hand, the RBC folate concentration levels were significantly increased in preterm newborns (median 1,212 ng/ml; p=0.01) in comparison with full-term newborns (median 1,098 ng/ml). Higher RBC folate concentration levels were found in newborns which had been delivered by Caesarean section (median 1,188 ng/ml; p=0.02) compared to those born vaginally (median 1,098 ng/ml). CONCLUSION Our results confirmed a significant decrease in RBC folate concentration in asphyxiated newborns on their first day of life (Fig. 4, Ref. 36). |
| Databáze: | OpenAIRE |
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