The Australian polidocanol (aethoxysklerol) study. Results at 2 years
Autor: | P. Conrad, G. M. Malouf, Michael Stacey |
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Rok vydání: | 1995 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Hypertonic Solutions Polidocanol Dermatology Polyethylene Glycols Sodium Tetradecyl Sulfate Varicose Veins Double-Blind Method Varicose veins Sclerotherapy Medicine Humans Telangiectasis Anesthetics Local Prospective cohort study Telangiectasia business.industry Sclerosing Solutions General Medicine Sodium tetradecyl sulfate Hypertonic saline Surgery medicine.symptom business medicine.drug |
Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 21(4) |
ISSN: | 1076-0512 |
Popis: | BACKGROUND An ongoing study of the safety and effectiveness of polidocanol by 98 investigators in Australia injecting 16,804 limbs over 2 years. OBJECTIVE To evaluate the complications of polidocanol and compare its effectiveness and complications with sodium tetra-decyl sulphate (STD) and hypertonic saline. METHODS A single-arm prospective study of polidocanol complications and its effectiveness as a sclerosant was performed. This was compared with each investigator's previous experience with other sclerosing agents. Patients had either varicose veins or venule ectasias and/or spider veins (telangiectasia). A total of 16,804 limbs were injected by 98 investigators. Sclerotherapy was performed with 0.5% or 1% polidocanol for telangiectasias or spider veins, and with 3% polidocanol for varicose veins. The effectiveness of the sclerotherapy and any complications were reported during a 2-year period. RESULTS There were very few complications reported with polidocanol. There were no reported deaths or anaphylaxis. The investigators with previous experience of other sclerosants considered that the effectiveness of polidocanol was superior to STD (85%) and hypertonic saline (84%). Ninety percent of investigators considered that polidocanol had less frequent complications than STD, and 80% considered that these were less severe. Seventy-four percent considered that polidocanol had fewer side effects than hypertonic saline, and 74% considered that these were less severe. CONCLUSIONS Polidocanol is an effective sclerosant that has few complications. |
Databáze: | OpenAIRE |
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