Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification
| Autor: | Philippe Pibarot, Anthony Poulin, George Thanassoulis, Yohan Bossé, Patrick Mathieu, R. Capoulade, Maxime Nadeau, Thierry Le Tourneau, James C. Engert, S. Matthijs Boekholdt, Christian Dina, Michel Tessier, Kay-Tee Khaw, Hao Yu Chen, Nicolas Perrot, Marie-Annick Clavel, Nicholas J. Wareham, Audrey-Anne Després, Sidwell Rigade, Sébastien Thériault, Jean Guimond, Jean-Jacques Schott, Mikaël Trottier, Benoit J. Arsenault, David Messika-Zeitoun, Marc R. Dweck |
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| Přispěvatelé: | Cardiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias, Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Aortic valve
Male medicine.medical_specialty Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Prospective Studies First-degree relatives Prospective cohort study Aged Clinical Trials as Topic business.industry Calcinosis Correction Calcific aortic valve stenosis Aortic Valve Stenosis medicine.disease Cardiac surgery Pedigree medicine.anatomical_structure Aortic valve stenosis Aortic Valve Cohort Cardiology cardiovascular system Female Cardiology and Cardiovascular Medicine business Genome-Wide Association Study Lipoprotein(a) |
| Zdroj: | JAMA cardiology, 4(7), 620-627. American Medical Association |
| ISSN: | 2380-6583 |
| Popis: | IMPORTANCE: Genetic variants at the LPA locus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. OBJECTIVE: To study the associations of LPA variants with CAVS in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein(a) (Lp[a]) levels showed evidence of aortic valve microcalcification. DESIGN, SETTING, AND PARTICIPANTS: This genetic association study included patients undergoing cardiac surgery from the Genome-Wide Association Study on Calcific Aortic Valve Stenosis in Quebec (QUEBEC-CAVS) study and patients with CAD, patients without CAD, and control participants from 6 genetic association studies: the UK Biobank, the European Prospective Investigation of Cancer (EPIC)-Norfolk, and Genetic Epidemiology Research on Aging (GERA) studies and 3 French cohorts. In addition, a family study included first-degree relatives of patients with CAVS. Data were collected from January 1993 to September 2018, and analysis was completed from September 2017 to September 2018. EXPOSURES: Case-control studies. MAIN OUTCOMES AND MEASURES: Presence of CAVS according to a weighted genetic risk score based on 3 common Lp(a)-raising variants and aortic valve microcalcification, defined as the mean tissue to background ratio of 1.25 or more, measured by fluorine 18-labeled sodium fluoride positron emission tomography/computed tomography. RESULTS: This study included 1009 individuals undergoing cardiac surgery and 1017 control participants in the QUEBEC-CAVS cohort; 3258 individuals with CAVS and CAD, 41 100 controls with CAD, 2069 individuals with CAVS without CAD, and 380 075 control participants without CAD in the UK Biobank, EPIC-Norfolk, and GERA studies and 3 French cohorts combined; and 33 first-degree relatives of 17 patients with CAVS and high Lp(a) levels (≥60 mg/dL) and 23 control participants with normal Lp(a) levels ( |
| Databáze: | OpenAIRE |
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