Four Yellow Monoterpenoid Quinoline Alkaloids from the Stem of Tabernaemontana bovina
| Autor: | Bao-Bao Shi, Yi Wang, Yang Yu, Mei-Fen Bao, Jing Wu, Xiang-Hai Cai, Johann Schinnerl |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
Models Molecular Tabernaemontana Stereochemistry Nitric oxide biosynthesis Crystallography X-Ray Nitric Oxide 010402 general chemistry 01 natural sciences Biochemistry Mice chemistry.chemical_compound Alkaloids Animals Physical and Theoretical Chemistry Molecular Structure biology 010405 organic chemistry Chemistry Macrophages Alkaloid Organic Chemistry Quinoline biology.organism_classification 0104 chemical sciences RAW 264.7 Cells Quinolines |
| Zdroj: | Organic Letters. 21:4554-4558 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.9b01453 |
| Popis: | Four unprecedented yellow alkaloids named as taberbovines A-D (1-4) were isolated from stems of Tabernaemontana bovina Lour. Their structures were elucidated by the comprehensive spectroscopic data, computational chemistry, and X-ray crystal diffraction. Alkaloids 1-4 possessed a unique 6/6/5/6/5 ring system and were assigned to monoterpenoid quinolines. Biosynthetically, the isolated alkaloids may be derived from Aspidosperma-type alkaloid by oxidation and rearrangements. Taberbovines A-D exhibited the good inhibitory activities of formation NO in LPS induced RAW264.7 macrophages. |
| Databáze: | OpenAIRE |
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