Risk factors for venous thromboembolism (VTE) recurrences in Thai patients without cancer
| Autor: | Panchalee Satpanich, Ponlapat Rojnuckarin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Thrombophilia 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors Internal medicine Neoplasms medicine Humans cardiovascular diseases Risk factor Aged Retrospective Studies business.industry Cancer Female sex Hematology Venous Thromboembolism Middle Aged medicine.disease Thailand Pulmonary embolism 030220 oncology & carcinogenesis Female Provoking factor business Venous thromboembolism 030215 immunology Follow-Up Studies |
| Zdroj: | Hematology (Amsterdam, Netherlands). 24(1) |
| ISSN: | 1607-8454 |
| Popis: | Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role. This study aimed to determine the incidence and risk factors of recurrent VTE in Asian patients.This is a retrospective cohort study in adult VTE patients who were diagnosed during 2004-2014, had no active cancer and followed-up for at least 1 year.There were 198 patients. The mean age was 58.2 ± 17.6 years and 68.2% were female. The diagnoses were deep vein thrombosis (56%), pulmonary embolism (32%) or both (12%). They were provoked by major surgery in 21.7%. Thrombophilia (antiphospholipid syndrome or protein C or protein S deficiency) was found in 11.6%. The recurrent rate during the median follow-up time of 52 months was 2.2 (95% confidence interval [CI] 1.46-3.31) per 100 patient-years. Presence of thrombophilia was independently associated with recurrences with the adjusted hazard ratio (aHR) of 3.52 (95% CI 1.32-9.42, p = 0.01). There were 144 patients who discontinued anticoagulants. During the median time of 55 months after stopping anticoagulants, the recurrent rate was 4.3 per 100 patient-years. Thrombophilia was associated with recurrences with aHR of 4.00 (95% CI 1.42-11.31, p = 0.01), while male sex, younger age, provoking conditions and hormone use showed no significant association.VTE recurrent rate in Asians is comparable to Caucasians, but thrombophilia is the strongest risk factor. |
| Databáze: | OpenAIRE |
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