Antimicrobial Activities of Hexane Extract and Decussatin from Stembark Extract of Ficus congensis
| Autor: | Silva Iwuanyanwu, Adesegun Sunday, Nisha Singh, GA Ayoola, Chinwendum Stephenie Alaribe, Herbert A. B. Coker, Francis Shode |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Xanthones Molecular Conformation Microbial Sensitivity Tests Trichophyton rubrum Gram-Positive Bacteria decussatin Moraceae Article Catalysis Aspergillus fumigatus Microbiology lcsh:Chemistry Inorganic Chemistry chemistry.chemical_compound Anti-Infective Agents Candida albicans Gram-Negative Bacteria Xanthone Hexanes DAD Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy biology Traditional medicine Plant Extracts Organic Chemistry Broth microdilution General Medicine Ficus biology.organism_classification Antimicrobial Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 chemistry antimicrobial MHB Antibacterial activity Ficus congensis |
| Zdroj: | International Journal of Molecular Sciences, Vol 12, Iss 4, Pp 2750-2756 (2011) International Journal of Molecular Sciences Volume 12 Issue 4 Pages 2750-2756 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms12042750 |
| Popis: | Ficus congensis (Moraceae) is used traditionally in the treatment of various diseases including infectious diseases, infertility, and gastrointestinal disorders. Investigation of hexane extract of the stem bark using chromatographic techniques led to isolation of a xanthone, 1-hydroxy-3,7,8-trimethoxyxanthone (Decussatin). The compound was elucidated based on spectroscopic methods such as nuclear magnetic resonance (NMR), UV, IR, and mass spectrometry (MS). Decussatin and the hexane extract were screened in vitro for antibacterial and antifungal activities using broth microdilution (MHB) and disc Agar diffusion (DAD) techniques against Escheichia coli, Bacilus substilis, Klebsiela pneumonia, Staphylococcus aureus, Aspergillus fumigatus, Trichophyton mentagrophytes, Trichophyton rubrum and Candida albicans. Hexane extracts showed potent antibacterial activity against E. coli and B. subtilis with minimum inhibitory concentrations (MIC) of 8 mg/mL and 5 mg/mL, respectively, while Decussatin of the highest concentration (8 mg/mL) used in this study showed no appreciable antimicrobial activity. Only hexane extract was active against C. albicans with a MIC of 1 mg/mL. |
| Databáze: | OpenAIRE |
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