Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
| Autor: | Cole, James H., Annus, Tiina, Wilson, Liam R., Remtulla, Ridhaa, Hong, Young T., Fryer, Tim D., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Smith, Robert, Menon, David K., Zaman, Shahid H., Nestor, Peter J., Holland, Anthony J. |
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| Přispěvatelé: | Menon, David [0000-0002-3228-9692], Zaman, Shahid [0000-0003-1639-6014], Holland, Anthony [0000-0003-4107-130X], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Aging Down syndrome metabolism [Amyloid beta-Peptides] Cognitive decline Neuroimaging pathology [Aging] Cognition pathology [Brain] Machine learning psychology [Aging] Humans ddc:610 metabolism [Aging] diagnostic imaging [Brain] pathology [Down Syndrome] Aged Amyloid beta-Peptides physiology [Cognition] Brain Regular Article Middle Aged Magnetic Resonance Imaging Brain aging metabolism [Brain] Amyloid PET Positron-Emission Tomography psychology [Down Syndrome] Female metabolism [Down Syndrome] diagnostic imaging [Down Syndrome] MRI |
| Zdroj: | Neurobiology of Aging Neurobiology of aging 56, 41-49 (2017). doi:10.1016/j.neurobiolaging.2017.04.006 Cole, J H, Annus, T, Wilson, L R, Remtulla, R, Hong, Y T, Fryer, T D, Acosta-Cabronero, J, Cardenas-Blanco, A, Smith, R, Menon, D K, Zaman, S H, Nestor, P J & Holland, A J 2017, ' Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline ', Neurobiology of Aging, vol. 56, pp. 41-49 . https://doi.org/10.1016/j.neurobiolaging.2017.04.006 |
| ISSN: | 1558-1497 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.04.006 |
| Popis: | Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease—factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS (N = 46) and typically developing controls (N = 30). Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference (brain-PAD) score. DS participants also underwent [11C]-PiB positron emission tomography (PET) scans to index the levels of cerebral beta amyloid deposition, and cognitive assessment. Mean brain-PAD in DS participants’ was +2.49 years, significantly greater than controls (p < 0.001). The variability in brain-PAD was associated with the presence and the magnitude of PiB-binding and levels of cognitive performance. Our study indicates that DS is associated with premature structural brain aging, and that age-related alterations in brain structure are associated with individual differences in the rate of beta amyloid deposition and cognitive impairment. |
| Databáze: | OpenAIRE |
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