Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
| Autor: | Xiaoyan Wu, Ying Cao, Ziwei Xu, Linjie Zhang, Zi-Mo Chen, Pingzheng Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Inflammasomes THIK-1 Potassium Immunology chemistry.chemical_element Review Ion Channels 03 medical and health sciences 0302 clinical medicine inflammasome NLR Family Pyrin Domain-Containing 3 Protein medicine Animals Humans Immunology and Allergy K2P channels Ion channel Innate immune system integumentary system Pyroptosis pannexin-1 Inflammasome Pannexin Gasdermin D Cell biology 030104 developmental biology chemistry P2X7 receptor TWIK protein-related acid-sensitive potassium channel 2 Efflux NLRP3 inflammasome activation lcsh:RC581-607 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.609441 |
| Popis: | The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases. Potassium efflux has been reported to be essential for NLRP3 inflammasome activation by structurally diverse pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Thus, the molecular mechanisms underlying potassium efflux to activate NLRP3 inflammasome are under extensive investigation. Here, we review current knowledge about the distinction channels or pore-forming proteins underlying potassium efflux for NLRP3 inflammasome activation with canonical/non-canonical signaling or following caspase-8 induced pyroptosis. Ion channels and pore-forming proteins, including P2X7 receptor, Gasdermin D, pannexin-1, and K2P channels involved present viable therapeutic targets for NLRP3 inflammasome related diseases. |
| Databáze: | OpenAIRE |
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