Human Adenovirus 36 Infection Increased the Risk of Obesity: A Meta-Analysis Update
| Autor: | Kai-Li Chen, Jian Yin, Mai Shi, Dongfang Wang, Mei-Yan Xu, Qing-Bin Lu, Jing-Hui Guo, Bing Cao |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Population Subgroup analysis Epidemiological method Body Mass Index Adenovirus Infections Human Risk Factors Internal medicine medicine Humans Obesity education Child education.field_of_study business.industry General Medicine Odds ratio medicine.disease eye diseases Meta-analysis Immunology ComputingMethodologies_DOCUMENTANDTEXTPROCESSING medicine.symptom business Body mass index Weight gain Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Supplemental Digital Content is available in the text Human adenovirus 36 (HAdV-36), as the key pathogen, was supposed and discussed to be associated with obesity. We searched the references on the association between HAdV-36 infection and obesity with the different epidemiological methods, to explore the relationship with a larger sample size by meta-analysis and compare the differences of epidemiological methods and population subsets by the subgroup analyses. We conducted literature search on the association between HAdV-36 infections and obesity in English or Chinese published up to July 1, 2015. The primary outcome was the HAdV-36 infection rate in the obese and lean groups; the secondary outcomes were the BMI level and BMI z-score in the HAdV-36 positive and negative groups. The pooled odds ratio (OR) was calculated for the primary outcome; the standardized mean differences (SMDs) were calculated for the secondary and third outcomes. Prediction interval (PI) was graphically presented in the forest plot of the random effect meta-analyses. Metaregression analysis and subgroup analysis were performed. Finally 24 references with 10,191 study subjects were included in the meta-analysis. The obesity subjects were more likely to be infected with HAdV-36 compared to the lean controls (OR = 2.00; 95%CI: 1.46, 2.74; PI: 0.59, 6.76; P |
| Databáze: | OpenAIRE |
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