Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives
| Autor: | Robert L. Smith, Ta-Jyh Lee, Norman P. Gould, Edward J. Cragoe, Helen G. Oien, Frederick A. Kuehl |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Stereochemistry Receptors Prostaglandin Rat kidney Prostaglandin In Vitro Techniques Kidney Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Cyclic AMP Animals Prostaglandin receptor Mouse Ovary CAMP formation Aza Compounds Prostaglandins E Fatty Acids Ovary Heptanoic acid Prostanoic Acids Rats chemistry Molecular Medicine Female |
| Zdroj: | Journal of Medicinal Chemistry. 20:1292-1299 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00220a013 |
| Popis: | A series of novel (8-aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids has been synthesized and evaluated for their ability to mimic the E series prostaglandins in stimulating cAMP formation in the mouse ovary and in binding to the rat kidney plasma prostaglandin receptor. 7-[2-(3-Hydroxyoctyl)-1,1,4-trioxo-3-thiazolidinyl]heptanoic acid markedly stimulates cAMP formation at reasonable pharmacological concentrations and avidly binds to the rat kidney prostaglandin receptor. |
| Databáze: | OpenAIRE |
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