Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases
| Autor: | Alejandro Sosnik, Diego A. Chiappetta, Katia Pamela Seremeta, Julieta Celeste Imperiale |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Chemistry
Pharmaceutical PEDIATRIC DRUG DELIVERY AND FORMULATIONS Antitubercular Agents Pharmaceutical Science Developing country HIV Infections INGENIERÍAS Y TECNOLOGÍAS Pharmacology Antiviral Agents Pediatrics Infant Newborn Diseases World health Antimalarials Drug Delivery Systems Nanocapsules Humans Technology Pharmaceutical Tuberculosis Medicine Child Developing Countries Poverty Nanotecnología business.industry Drug Administration Routes Infant Newborn Infant Public relations Nano-materiales Infant newborn PHARMACOTHERAPY OF POVERTY-RELATED DISEASES Malaria Child Preschool Drug delivery business Clinical evaluation Tablets |
| Zdroj: | Expert Opinion on Drug Delivery. 9:303-323 |
| ISSN: | 1744-7593 1742-5247 |
| Popis: | INTRODUCTION: Due to a lack of approved drugs and formulations, children represent the most vulnerable patients. Magistral, unlicensed formulations obtained by the manipulation of solid forms should undergo clinical evaluation to ensure bioequivalence. The development of new pediatric medicines is complex and faces technological, economic and ethical challenges. This phenomenon has contributed to the emergence of an adult-children gap. To improve the situation, the World Health Organization launched the global campaign ´Make medicines child size´ and a number of international initiatives have been established. The situation is more critical in the case of poverty-related diseases (PRDs) that mainly affect poor countries. AREAS COVERED: This review critically discusses different strategies to develop pediatric formulations and drug delivery systems (DDS) in PRDs and their potential implementation in the current market. Readers will gain an updated perspective on the development of pediatric medicines for the treatment of PRDs and the proximate challenges and opportunities faced to ensure an effective pharmacotherapy. EXPERT OPINION: There is an urgent need for the development of innovative, scalable and cost-viable formulations to ensure pediatric patients have access to appropriate medications for PRDs. The guidelines of the International Conference on Harmonisation constitute a very good orientation tool, as they emphasize physiological and developmental aspects that need to be considered in pediatric research. It is important to consider cultural, economic and ethical aspects that make developing nations facing PRDs different from the developed world. Thus, the best strategy would probably be to conceive and engage similar initiatives in the developing world, to address unattended therapeutic niches. Fil: Sosnik, Alejandro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Seremeta, Katia Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Imperiale, Julieta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina |
| Databáze: | OpenAIRE |
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