Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids
| Autor: | Juma'a R. Al Dulayymi, Mark S. Baird, Omar T. Ali, Mohsin O. Mohammed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Glycerol
Stereochemistry mycobacteria Pharmaceutical Science Chemistry Techniques Synthetic 01 natural sciences Article Hydrolysate Mycobacterium Analytical Chemistry Mycobacterial cell Cell membrane Cell wall lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound lcsh:Organic chemistry Cell Wall Drug Discovery medicine mycolic acids Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences Molecular Structure 010405 organic chemistry Chemistry Fragment (computer graphics) Organic Chemistry Stereoisomerism Arabinose 0104 chemical sciences Coupling (electronics) medicine.anatomical_structure Chemistry (miscellaneous) triarabinoglycerol Molecular Medicine Stereoselectivity Trisaccharides cell membrane |
| Zdroj: | Molecules, Vol 24, Iss 19, p 3596 (2019) Molecules Volume 24 Issue 19 |
| ISSN: | 1420-3049 |
| Popis: | Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties. A related di-mycoloyl tri-arabinofuranosyl glycerol fragment has been isolated from cell wall hydrolysates. An effective stereoselective synthesis of tri-arabinofuranosyl glycerol, followed by coupling with stereochemically defined mycolic acids of different structural classes, to provide unique di-mycoloyl tri-arabinofuranosyl glycerols is now described. |
| Databáze: | OpenAIRE |
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