| Autor: |
John H Page, Ajit A Londhe, Corinne Brooks, Jie Zhang, J Michael Sprafka, Corina Bennett, Megan Braunlin, Carolyn A Brown, Prista Charuworn, Alvan Cheng, Karminder Gill, Fang He, Junjie Ma, Jeffrey Petersen, Olulade Ayodele, Ying Bao, Katherine B Carlson, Shun-Chiao Chang, Giovanna Devercelli, Michele Jonsson-Funk, Jenny Jiang, Hillary A Keenan, Kaili Ren, Kimberly A Roehl, Lynn Sanders, Luyang Wang, Zhongyuan Wei, Qian Xia, Peter Yu, Linyun Zhou, Julia Zhu, Kathleen Gondek, Cathy W Critchlow, Brian D Bradbury |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ Open. 12:e055137 |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-055137 |
| Popis: |
ObjectivesTo examine the temporal patterns of patient characteristics, treatments used and outcomes associated with COVID-19 in patients who were hospitalised for the disease between January and 15 November 2020.DesignObservational cohort study.SettingCOVID-19 subset of the Optum deidentified electronic health records, including more than 1.8 million patients from across the USA.ParticipantsThere were 51 510 hospitalised patients who met the COVID-19 definition, with 37 617 in the laboratory positive cohort and 13 893 in the clinical cohort.Primary and secondary outcome measuresIncident acute clinical outcomes, including in-hospital all-cause mortality.ResultsRespectively, 48% and 49% of the laboratory positive and clinical cohorts were women. The 50– 65 age group was the median age group for both cohorts. The use of antivirals and dexamethasone increased over time, fivefold and twofold, respectively, while the use of hydroxychloroquine declined by 98%. Among adult patients in the laboratory positive cohort, absolute age/sex standardised incidence proportion for in-hospital death changed by −0.036 per month (95% CI −0.042 to –0.031) from March to June 2020, but remained fairly flat from June to November, 2020 (0.001 (95% CI −0.001 to 0.003), 17.5% (660 deaths /3986 persons) in March and 10.2% (580/5137) in October); in the clinical cohort, the corresponding changes were −0.024 (95% CI −0.032 to –0.015) and 0.011 (95% CI 0.007 0.014), respectively (14.8% (175/1252) in March, 15.3% (189/1203) in October). Declines in the cumulative incidence of most acute clinical outcomes were observed in the laboratory positive cohort, but not for the clinical cohort.ConclusionThe incidence of adverse clinical outcomes remains high among COVID-19 patients with clinical diagnosis only. Patients with COVID-19 entering the hospital are at elevated risk of adverse outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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