Syntheses of crowned polyamines using isolable succinimidyl esters of N-tritylated linear amino acids and peptides
| Autor: | George Karigiannis Dimitrios Vahliotis, Giovanni Sindona, Charilaos Damianakos, Nikolaos Tsiakopoulos, Dionissios Papaioannou |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | ARKIVOC, Vol 2002, Iss 13, Pp 79-104 (2003) |
| ISSN: | 1551-7012 1551-7004 |
| Popis: | Partial and total syntheses of polyamines incorporating crown ether moieties have been effected using N-tritylated linear amino acids, like β-alanine (βAla) and γ-aminobutyric acid (γAba), to introduce the N-3-C and N-4-C polyamine structural units, respectively. The partial syntheses involve the acylation of commercially available crown bearing amino function(s) or aza-oxa crown ethers with the isolable succinimidyl esters of Trt-βAla-OH or Trt-βAla-γAba-OH, followed by LiAlH4-mediated reduction of the resulting amides, whereas in the total syntheses the crown and the aza-oxa crown ether moieties are built-up from commercially available starting materials like polyethylene glycols, epichlorohydrin and dibenzylamine. |
| Databáze: | OpenAIRE |
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