Translating Research for the Radiotheranostics of Nanotargeted 188Re-liposome

Autor: Chih-Hsien Chang, Ya-Jen Chang, Te-Wei Lee, Liang-Cheng Chen, Ming-Cheng Chang, Gann Ting
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Nuclear imaging
Drug Evaluation
Preclinical
Review
Theranostic Nanomedicine
Translational Research
Biomedical
lcsh:Chemistry
0302 clinical medicine
Neoplasms
Outcome Assessment
Health Care
Tissue Distribution
lcsh:QH301-705.5
Spectroscopy
nuclear imaging
Liposome
Clinical Studies as Topic
General Medicine
Computer Science Applications
Rhenium
030220 oncology & carcinogenesis
liposome
Nano Drug Delivery
Biodistribution
Single Photon Emission Computed Tomography Computed Tomography
nanoliposome
radiotheranostics
Catalysis
Inorganic Chemistry
03 medical and health sciences
In vivo
medicine
Animals
Humans
Physical and Theoretical Chemistry
Radiometry
Molecular Biology
Radioisotopes
Tomography
Emission-Computed
Single-Photon
business.industry
Organic Chemistry
Cancer
medicine.disease
030104 developmental biology
rhenium-188
lcsh:Biology (General)
lcsh:QD1-999
Liposomes
Cancer research
Nanoparticles
Radiopharmaceuticals
business
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 3868, p 3868 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Nanoliposomes are one of the leading potential nano drug delivery systems capable of targeting chemotherapeutics to tumor sites because of their passive nano-targeting capability through the enhanced permeability and retention (EPR) effect for cancer patients. Recent advances in nano-delivery systems have inspired the development of a wide range of nanotargeted materials and strategies for applications in preclinical and clinical usage in the cancer field. Nanotargeted 188Re-liposome is a unique internal passive radiotheranostic agent for nuclear imaging and radiotherapeutic applications in various types of cancer. This article reviews and summarizes our multi-institute, multidiscipline, and multi-functional studied results and achievements in the research and development of nanotargeted 188Re-liposome from preclinical cells and animal models to translational clinical investigations, including radionuclide nanoliposome formulation, targeted nuclear imaging, biodistribution, pharmacokinetics, radiation dosimetry, radiation tumor killing effects in animal models, nanotargeted radionuclide and radio/chemo-combination therapeutic effects, and acute toxicity in various tumor animal models. The systemic preclinical and clinical studied results suggest 188Re-liposome is feasible and promising for in vivo passive nanotargeted radionuclide theranostics in future cancer care applications.
Databáze: OpenAIRE
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