The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

Autor:	Alan L. Schechter, Jeffrey A. Drebin, David F. Stern, Mark I. Greene, Robert A. Weinberg, Stuart J. Decker, Lalitha Vaidyanathan
Rok vydání:	1984
Předmět:	animal structures Multidisciplinary Molecular mass Receptors Cell Surface Glioma Oncogenes Biology Cross Reactions Rats Gene product ErbB Receptors Molecular Weight Neuroblastoma Antigen Cell culture Epidermal growth factor Antigens Neoplasm Cancer research Animals Receptor Gene
Zdroj:	Nature. 312(5994)
ISSN:	0028-0836
Popis:	A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0768ee9f488ffad9be2c30f8dda81a3 https://pubmed.ncbi.nlm.nih.gov/6095109 Zobrazit plný text záznamu