Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production
| Autor: | Lucy A. Truman, Kevin L. Bentley, Nancy H. Ruddle |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Genetically modified mouse Pathology medicine.medical_specialty Transgene Immunology Lymphadenopathy Mice Transgenic Biology medicine.disease_cause Tear production Salivary Glands Autoimmunity 03 medical and health sciences Mice 0302 clinical medicine immune system diseases Cervical lymphadenopathy hemic and lymphatic diseases medicine Immunology and Allergy Animals Lymphotoxin-alpha Lacrimal Apparatus MALT lymphoma Lymphoma B-Cell Marginal Zone medicine.disease 030104 developmental biology Lymphotoxin Lymphatic system Sjogren's Syndrome Tertiary Lymphoid Structures Tears medicine.symptom 030215 immunology |
| Zdroj: | European journal of immunologyReferences. 50(3) |
| ISSN: | 1521-4141 |
| Popis: | To investigate the role of lymphotoxin (LT) in Sjogren's syndrome (SS) and in mucosal associated lymphoid tissue (MALT)-lymphoma, we made transgenic mice (Amy1-LTαβ) that targeted LTα and LTβ to the salivary and lacrimal glands. Amy1-LTαβ mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1-LTαβ mice developed cervical lymphadenopathy but not MALT-lymphoma. TLO formation in the salivary and lacrimal glands of Amy1-LTαβ was not sufficient to induce autoimmunity as measured by autoantibody titres. |
| Databáze: | OpenAIRE |
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