Metabolism and Urinary Excretion of Esmolol in Humans
| Autor: | James D. Hulse, Debra Drissel, Ramanuj Achari, William L. Matier |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Pharmacology Chemistry medicine.drug_class Urinary system Metabolite Adrenergic beta-Antagonists Metabolism Urine Esmolol Propanolamines Kinetics chemistry.chemical_compound Urinary excretion Pharmacokinetics medicine Humans Infusions Parenteral Pharmacology (medical) Beta blocker Biotransformation Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 26:44-47 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1986.tb02901.x |
| Popis: | The urinary excretion patterns of esmolol, a short-acting beta blocker, and its major metabolite were investigated in eight healthy men after intravenous infusion of 50, 100, 200, and 300 micrograms/kg/min of esmolol for six hours and 150 micrograms/kg/min for 24 hours. Esmolol and the metabolite concentrations in urine were determined by high-performance liquid chromatography. The mean urinary recoveries of the unchanged drug were 0.64%, 0.67%, 0.69%, 0.77%, and 0.98% after the 50, 100, 150, 200, and 300 micrograms/kg/min dose, respectively. Recovery of the metabolite was independent of dose, and the overall mean recovery accounted for 73% of administered dose. The results of this study indicate that esmolol is extensively metabolized, and the extent of the metabolism is not dose related in the dosage range used. The renal route plays a very minor role in the elimination of the drug but is important for the elimination of the metabolite. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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