Focused Ultrasound Thalamotomy for Refractory Essential Tremor: A Japanese Multicenter Single-Arm Study
| Autor: | Hidehiro Hirabayashi, Hajime Kamada, Hideyuki Ohnishi, Kazuhiko Sadamoto, Hiroki Hori, Hideki Mochizuki, Kenji Fukutome, Manabu Kanemoto, Keiji Igase, Kimito Kondo, Kazumichi Yamada, Ichiro Matsubara, Hironori Furukawa, Shiro Horisawa, Toshio Yamaguchi, Takanori Ohnishi, Keiichi Abe, Haruhiko Kishima, Takaomi Taira, Satoru Oshino |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Essential Tremor medicine.medical_treatment Confirmatory trial Cohort Studies Japan Thalamus Quality of life Surveys and Questionnaires Multicenter trial medicine Humans Prospective Studies Adverse effect Aged Aged 80 and over Essential tremor Thalamotomy business.industry Postural tremor Middle Aged medicine.disease Magnetic Resonance Imaging Treatment Outcome Anesthesia Cohort High-Intensity Focused Ultrasound Ablation Female Surgery Neurology (clinical) business |
| Zdroj: | Neurosurgery. 88:751-757 |
| ISSN: | 1524-4040 0148-396X |
| Popis: | BACKGROUND Several feasibility studies and a randomized, controlled, multicenter trial have demonstrated the safety and efficacy of unilateral transcranial magnetic resonance-guided focused ultrasound (FUS) lesioning of the ventral intermediate thalamic nucleus in treating essential tremor. OBJECTIVE To evaluate the safety and efficacy of FUS thalamotomy in a Japanese patient cohort through a prospective, multicenter, single-arm confirmatory trial. METHODS A total of 35 patients with disabling refractory essential tremor underwent unilateral FUS thalamotomy and were followed up for 12 post-treatment months. Safety was measured as the incidence and severity of treatment-related adverse events. Efficacy was measured as the tremor severity and quality of life improvements using the Clinical Rating Scale for Tremor and Questionnaire for Essential Tremor. RESULTS The mean skull density ratio (SDR) was 0.47. There was a significant decrease in the mean postural tremor score of the treated hand from baseline to 12 mo by 56.4% (95% CI: 46.7%-66.1%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|