Molecules and mechanisms to overcome oxidative stress inducing cardiovascular disease in cancer patients
| Autor: | Chiara Carlomagno, Vincenzo Tortora, Amelia Filippelli, Luigi Liguori, Carmine Vecchione, Francesco Sabbatino, Valeria Conti, Graziamaria Corbi, Valentina Manzo, Stefano Pepe, Giovanna Polcaro |
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| Přispěvatelé: | Sabbatino, F., Conti, V., Liguori, L., Polcaro, G., Corbi, G., Manzo, V., Tortora, V., Carlomagno, C., Vecchione, C., Filippelli, A., Pepe, S. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Review Disease 030204 cardiovascular system & hematology medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Detoxification medicine Antioxidative treatment Cardiotoxicity Cardiovascular disease Endothelial dysfunction Oncological treatments Oxidative stress ROS lcsh:Science Ecology Evolution Behavior and Systematics chemistry.chemical_classification Reactive oxygen species Oncological treatment business.industry Paleontology Cancer medicine.disease 030104 developmental biology chemistry Space and Planetary Science Cancer research Oxidative stre lcsh:Q Signal transduction business |
| Zdroj: | Life, Vol 11, Iss 105, p 105 (2021) Life |
| Popis: | Reactive oxygen species (ROS) are molecules involved in signal transduction pathways with both beneficial and detrimental effects on human cells. ROS are generated by many cellular processes including mitochondrial respiration, metabolism and enzymatic activities. In physiological conditions, ROS levels are well-balanced by antioxidative detoxification systems. In contrast, in pathological conditions such as cardiovascular, neurological and cancer diseases, ROS production exceeds the antioxidative detoxification capacity of cells, leading to cellular damages and death. In this review, we will first describe the biology and mechanisms of ROS mediated oxidative stress in cardiovascular disease. Second, we will review the role of oxidative stress mediated by oncological treatments in inducing cardiovascular disease. Lastly, we will discuss the strategies that potentially counteract the oxidative stress in order to fight the onset and progression of cardiovascular disease, including that induced by oncological treatments. |
| Databáze: | OpenAIRE |
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