An emerging role for BAG3 in gynaecological malignancies
| Autor: | Liberato Marzullo, Francesco De Caro, Massimiliano Chetta, Maurizio Guida, Vladimir N. Uversky, Antonio Raffone, Margot De Marco, Mario Capunzo, Giovanni Genovese, Antonia Falco, Roberta Iaccarino, Alessandra Rosati, Maria Caterina Turco, Antonio Mollo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Genital Neoplasms Female Review Article BAG3 medicine.disease_cause Virus Malignant transformation 03 medical and health sciences 0302 clinical medicine medicine Humans Neoplasm Invasiveness Cytoskeleton Adaptor Proteins Signal Transducing business.industry Autophagy medicine.disease Survival Analysis Gene Expression Regulation Neoplastic Oncology Dysplasia Apoptosis Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research Female Neoplasm Grading Carcinogenesis business Apoptosis Regulatory Proteins |
| Zdroj: | Br J Cancer |
| Popis: | BAG3, a member of the BAG family of co-chaperones, is a multidomain protein with a role in several cellular processes, including the control of apoptosis, autophagy and cytoskeletal dynamics. The expression of bag3 is negligible in most cells but can be induced by stress stimuli or malignant transformation. In some tumours, BAG3 has been reported to promote cell survival and resistance to therapy. The expression of BAG3 has been documented in ovarian, endometrial and cervical cancers, and studies have revealed biochemical and functional connections of BAG3 with proteins involved in the survival, invasion and resistance to therapy of these malignancies. BAG3 expression has also been shown to correlate with the grade of dysplasia in squamous intraepithelial lesions of the uterine cervix. Some aspects of BAG3 activity, such as its biochemical and functional interaction with the human papillomavirus proteins, could help in our understanding of the mechanisms of oncogenesis induced by the virus. This review aims to highlight the potential value of BAG3 studies in the field of gynaecological tumours. |
| Databáze: | OpenAIRE |
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