Unexpected overdose of oral cyclosporine in a kidney transplant patient: a case report
| Autor: | Astrid Bacle, Marion Mercerolle, Cécile Vigneau, Brendan Le Daré, Pascal Le Corre, Roxane Lhermitte, Jonathan Maurice Chemouny |
|---|---|
| Přispěvatelé: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Rok vydání: | 2021 |
| Předmět: |
safety
[SDV]Life Sciences [q-bio] kidney transplantation 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Therapeutic index case reports medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Medical prescription Kidney transplantation medicine.diagnostic_test business.industry Dosing regimen medicine.disease kidney failure 3. Good health chronic Clinical pharmacy Transplantation Therapeutic drug monitoring drug-related side effects and adverse reactions Anesthesia Solid organ transplantation business |
| Zdroj: | European Journal of Hospital Pharmacy European Journal of Hospital Pharmacy, BMJ Group, 2021, ejhpharm-2021-002730. ⟨10.1136/ejhpharm-2021-002730⟩ European Journal of Hospital Pharmacy, 2021, ejhpharm-2021-002730. ⟨10.1136/ejhpharm-2021-002730⟩ |
| ISSN: | 2047-9964 2047-9956 |
| DOI: | 10.1136/ejhpharm-2021-002730 |
| Popis: | International audience; Cyclosporine is a widely used immunosuppressive agent to prevent rejection of solid organ transplant. Here, we describe the case of a 71-year-old man who received the prescribed dose of cyclosporine 10 times 6 days after a kidney transplantation because of a concentration miscalculation involving two galenic forms. The patient presented gastrointestinal and neurological disorders. Therapeutic drug monitoring revealed high cyclosporine blood concentrations (693 ng/mL, therapeutic range 100-300 ng/mL). Symptomatic management of digestive disorders was performed, and haemodialysis was started the day after the cyclosporine overdose in the face of acute renal failure. The patient’s disorders were quickly resolved. The dosing regimen was adapted in order to administer the most appropriate galenic form and to avoid another administration error. Long-term follow-up showed no failure of renal transplantation. The purpose of this case report is to warn physicians and clinical pharmacists about the vigilance required on cyclosporine prescription, especially when two galenic forms are administered to obtain the prescribed dose. |
| Databáze: | OpenAIRE |
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