pH and DNA luminescence switching, DNA photocleavage and cytotoxic properties of two thiophene-containing ruthenium(II) complexes
| Autor: | Ping Liu, An-Guo Zhang, Xiao-Long Zhao, Xiao-Mei Song, Ke-Zhi Wang, Zhen-Sheng Li |
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| Rok vydání: | 2014 |
| Předmět: |
Luminescence
Light Light switch Stereochemistry chemistry.chemical_element Antineoplastic Agents Thiophenes Ruthenium Structure-Activity Relationship chemistry.chemical_compound Coordination Complexes Neoplasms Drug Discovery Organometallic Compounds Tumor Cells Cultured Thiophene Animals Humans A-DNA DNA Cleavage Cytotoxicity Cell Proliferation Pharmacology Molecular Structure Chemistry Organic Chemistry DNA General Medicine Hydrogen-Ion Concentration Quantum Theory Cattle Density functional theory |
| Zdroj: | European Journal of Medicinal Chemistry. 87:10-22 |
| ISSN: | 0223-5234 |
| Popis: | Two new Ru(II) complexes, [Ru(Htip)3]Cl2 (1) and [Ru(Htip)2(dppz)]Cl2 (2), were synthesised and were characterised. The ground- and excited-state acid–base properties of 1 and 2 were studied and demonstrated that 1 acted as a pH-induced “on–off–on” luminescence switch. The binding behaviours of 1 and 2 to calf thymus DNA were studied with absorption and emission spectroscopy, DNA viscosities and density functional theory calculations. 2 was found to act as a DNA molecular light switch and as an efficient photocleaver of pUC 18 DNA. The cytotoxicities of the complexes were evaluated with the MTT method and it was found that 1 displayed apparent anticancer activity against MCF-7 cell, whereas 2 exhibited more potent and wider-spectrum antitumor activities against all cancer cell lines tested. |
| Databáze: | OpenAIRE |
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