Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice
| Autor: | Youwei Wang, Qigui Mo, Jing Tong, Bingxin Ma, Gao Zhou, Jingsheng He |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Jatrorrhizine Coptisine medicine.medical_treatment Medicine (miscellaneous) Pharmacology 03 medical and health sciences chemistry.chemical_compound Diabetic 0404 agricultural biotechnology Berberine medicine α-Amylase TX341-641 heterocyclic compounds Coptis chinensis inflorescence 3T3-L1 Acarbose 030109 nutrition & dietetics Nutrition and Dietetics biology Streptozotocin Nutrition. Foods and food supply Insulin Palmatine 04 agricultural and veterinary sciences Coptis chinensis biology.organism_classification 040401 food science α-Glucosidase Biochemistry chemistry Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods, Vol 21, Iss, Pp 455-462 (2016) |
| ISSN: | 1756-4646 |
| Popis: | Coptis chinensis inflorescence is rich in isoquinoline alkaloids, especially berberine; these alkaloids comprise a chemical group with anti-hyperglycaemic effect. This study mainly investigated the α-amylase and α-glucosidase inhibitory activities of C. chinensis inflorescence extract (CE). The effect of CE was similar to that of acarbose. Results of 3T3-L1 preadipocyte assay showed that CE can increase glucose consumption. In addition, CE and its main alkaloids (jatrorrhizine, columbamine, epiberberine, coptisine, palmatine, and berberine) were used to ameliorate streptozotocin-induced diabetic mice. Anti-hyperglycaemic activity was realised by reducing the blood glucose level and increasing the insulin content. Furthermore, CE and its main alkaloids can relieve liver injury and lipid metabolic disturbance. Therefore, CE exerts anti-hyperglycaemic activity, and alkaloids may be an active compound group. Overall, the results provide scientific foundation for C. chinensis inflorescence as functional food to ameliorate hyperglycaemia. |
| Databáze: | OpenAIRE |
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