Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria -associated anaemia in Nigerian children during seven years of adoption as first-line treatments

Autor: P. U. Agomo, Folasade O. Ibironke, Henrietta U. Okafor, Christian T. Happi, Temitope Aderoyeje, William N. Ogala, Adejumoke I. Ayede, Elsie O. Adewoye, Godwin Ntadom, Ismaila Watila, Grace O. Gbotosho, Kazeem Akano, Chimere Agomo, Onikepe A. Folarin, Akintunde Sowunmi, Bayo Fatunmbi, Stephen Oguche, Martin M Meremikwu
Rok vydání: 2017
Předmět:
Male
“Haematocrit conservation”
chemistry.chemical_compound
0302 clinical medicine
030212 general & internal medicine
Artemether
Malaria
Falciparum
Artemisinin
Child
Children
biology
Anemia
General Medicine
Artemisinins
Artemisinin-based combination treatments
Drug Combinations
Treatment Outcome
Infectious Diseases
Hematocrit
Ethanolamines
Child
Preschool
Female
Malaria-associated anaemia
Research Article
medicine.drug
medicine.medical_specialty
Adolescent
030231 tropical medicine
Nigeria
Amodiaquine
Lumefantrine
Antimalarials
03 medical and health sciences
Internal medicine
medicine
Humans
Fluorenes
business.industry
Artemether
Lumefantrine Drug Combination
Public Health
Environmental and Occupational Health
Infant
Plasmodium falciparum
medicine.disease
biology.organism_classification
Surgery
Clinical trial
chemistry
Tropical medicine
business
Malaria
Zdroj: Infectious Diseases of Poverty
ISSN: 2049-9957
DOI: 10.1186/s40249-016-0217-7
Popis: Artemisinin-based combination treatments (ACTs) are the first-line treatments of uncomplicated Plasmodium falciparum malaria in many endemic areas but there are few evaluation of their efficacy in anaemic malarious children. Therapeutic efficacy of 3-day regimens of artesunate-amodiaquine and artemether-lumefantrine was evaluated in 437 anaemic and 909 non-anaemic malarious children following treatment during a seven-year period (2008–2014). Patterns of temporal changes in haematocrit were classified based on haematocrit values
Databáze: OpenAIRE
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