| Autor: |
Craig R. Miller, Erin L. Johnson, F. Marty Ytreberg, Tanya A. Miura, Celeste J. Brown, Kyle P. Martin, Holly A. Wichman, Aran Z. Burke |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Biophysical Journal. 110(3) |
| ISSN: |
0006-3495 |
| DOI: |
10.1016/j.bpj.2015.11.2643 |
| Popis: |
The 2014 Ebola virus outbreak in West Africa was the largest in recorded history and resulted in over 11,000 deaths. It is important to develop strategies for treatment and containment to avoid future epidemics of this magnitude. One strategy is to anticipate how the evolution of the virus might compromise treatment efforts. In this presentation I will show results from a molecular modeling study of the Ebola virus glycoprotein. As part of this study we have initiated a watch list of mutations that could potentially reduce the effectiveness of vaccines and antibody therapies. The list was generated by considering every possible mutation of the glycoprotein and including those that disrupt binding to protective antibodies but do not disrupt the protein function. This study emphasizes the need for more experimental structures of Ebola in order to expand the watch list. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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