Prevalence of positive screening test results and agreement between cytology and human papillomavirus testing in primary cervical cancer screening in North-Western Romania
| Autor: | Florian Nicula, Daniela Coza, Mihaiela L. Blaga, Rodica Pais, Maarit K. Leinonen, Elisabete Weiderpass, Mari Nygård, Dana Hashim, Trude Andreassen, Patriciu Achimaș Cadariu, Adriana Melnic, Ofelia Suteu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Epidemiology Population Ethnic group Uterine Cervical Neoplasms Pilot Projects Cervix Uteri Alphapapillomavirus 03 medical and health sciences 0302 clinical medicine Cytology medicine Prevalence Humans Mass Screening 030212 general & internal medicine education Cervix Early Detection of Cancer Vaginal Smears education.field_of_study Obstetrics business.industry Romania Public health Papillomavirus Infections Public Health Environmental and Occupational Health Cancer Middle Aged medicine.disease Uterine Cervical Dysplasia Test (assessment) medicine.anatomical_structure Cross-Sectional Studies Oncology Molecular Diagnostic Techniques 030220 oncology & carcinogenesis DNA Viral Feasibility Studies Female business Papanicolaou Test |
| Zdroj: | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 29(2) |
| ISSN: | 1473-5709 |
| Popis: | Using data from a pilot study conducted in North-Western Romania, we aimed to estimate the prevalence of abnormal cytology and positive high-risk human papillomavirus (hr-HPV) test results in an ethnically diverse screening population and to assess the agreement between cytology and hr-HPV testing to evaluate the feasibility of integrating the latter as a primary test in the national cervical cancer screening program. The cross-sectional pilot study included Roma women, other ethnic minorities, and women in rural remote areas. Samples were taken for liquid-based cytology and hr-HPV testing (Hybrid Capture 2 DNA test) by a mobile health unit. The prevalence of positive screening results and the agreement between cytology and hr-HPV testing were estimated by κ coefficient. A total of 1019 women were included in the study. The population prevalence of positive screening results was similar for both tests (12%). The prevalence of abnormal cytology increased with increasing age, whereas the prevalence of positive hr-HPV test showed a bimodal age pattern. Substantial differences in the prevalence of abnormal cytology were found by ethnicity, with highest prevalence in Romanian women (14%), followed by Roma women (6%) and women of other ethnicities (5%) (P = 0.002). Similar ethnic differences in the prevalence of positive hr-HPV test were not observed. The overall agreement of positive screening results between the two methods was fair (κ = 0.25; 95% confidence interval = 0.18-0.30, P |
| Databáze: | OpenAIRE |
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