Longitudinal study of bone loss in chronic spinal cord injury patients
| Autor: | Yesim Akkoc, Yesim Kirazli, Kazim Çapaci, Kamil Kumanlioglu, Inanc Karapolat, Hale Karapolat |
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| Přispěvatelé: | Ege Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Bone mineral
medicine.medical_specialty Pathology Deoxypyridinoline Bone loss biology business.industry Osteoporosis Urology Parathyroid hormone Physical Therapy Sports Therapy and Rehabilitation Spinal cord injury medicine.disease Bone remodeling chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Osteocalcin biology.protein Bone mineral density Original Article business Femoral neck |
| Zdroj: | Journal of Physical Therapy Science |
| Popis: | WOS: 000356074700034 PubMed ID: 26157234 [Purpose] This prospective longitudinal study evaluated the changes in bone metabolism markers and bone mineral density of spinal cord injury patients over 3 years. We also assessed the relationships among the bone mineral density, bone metabolism, and clinical data of spinal cord injury patients. [Subjects and Methods] We assessed the clinical data (i.e., immobilization due to surgery, neurological status, neurological level, and extent of lesion) in 20 spinal cord injury patients. Bone mineral density, and hormonal and biochemical markers of the patients were measured at 0, 6, 12, and 36 months. [Results] Femoral neck T score decreased significantly at 36 months (p < 0.05). Among the hormonal markers, parathyroid hormone and vitamin D were significantly elevated, while bone turnover markers (i.e., deoxypyridinoline and osteocalcin) were significantly decreased at 12 and 36 months (p < 0.05). [Conclusion] Bone mineral density of the femoral neck decreases significantly during the long-term follow-up of patients with spinal cord injury due to osteoporosis. This could be due to changes in hormonal and bone turnover markers. |
| Databáze: | OpenAIRE |
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