Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum
| Autor: | Fangfang Liu, Javier Perez-Irizarry, Kimberly L. Johung, Sajid A. Khan, Daniel J. Boffa, Gabriella Grisotti, Rebecca Zhu, Yawei Zhang, Charles Cha, Caroline H. Johnson, Dale Han |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Stromal cell medicine.medical_treatment Rectum Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Adjuvant therapy Medicine Gastrointestinal stromal tumors (GISTs) 030212 general & internal medicine Surgical treatment neoplasms business.industry Tumor biology Stomach medicine.disease digestive system diseases medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Original Article business Adjuvant |
| Zdroj: | Journal of Gastrointestinal Oncology. 9:231-240 |
| ISSN: | 2219-679X 2078-6891 |
| Popis: | Background Colon and rectal gastrointestinal stromal tumors (GISTs) are rare and poorly characterized. Because the majority of treatment guidelines for GISTs are extrapolated from tumors of gastric and small bowel origin, our aim was to better characterize the unique clinicopathologic features and prognostic factors of colon and rectal GISTs to guide clinical care. Methods The National Cancer Data Base (NCDB) was queried from 2006 to 2013 for cases of GISTs in the stomach, colon, and rectum. Patient demographics, clinical characteristics, and survival were compared. Results A total of 11,302 gastric GISTs were compared to 398 colon and 393 rectal GISTs. After propensity matching, compared to gastric GISTs, rectal GISTs had improved overall survival (HR =0.695, P=0.0264), while colon GISTs had worse overall survival (HR =1.6, P=0.0005). Surgical treatment for rectal GISTs was more likely to be local excision compared to colonic GISTs (51.1% vs. 8.4%, P |
| Databáze: | OpenAIRE |
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