Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro
| Autor: | Jian-Jun Wang, Jing-Ning Zhu, Hong-Zhao Li, Kun Chen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Histamine Antagonists Histamine H1 receptor In Vitro Techniques Pharmacology Biology Histamine Agonists Rats Sprague-Dawley chemistry.chemical_compound Histamine receptor Histamine H2 receptor Internal medicine medicine Animals Receptors Histamine H2 Red Nucleus Neurons General Neuroscience Histaminergic Dimaprit Rats Electrophysiology Endocrinology chemistry Histamine H3 receptor Histamine |
| Zdroj: | Neuroscience Letters. 351:25-28 |
| ISSN: | 0304-3940 |
| Popis: | Perfusing slices with histamine (1-100 microM) produced an excitatory response in rat rubral neurons (118/132, 89.4%). The histamine-induced excitation was not blocked by the low-Ca2+/high-Mg2+ medium (n=10), supporting a direct postsynaptic action of the amine. Histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of rubral neurons to histamine (n=26), but H1 receptor antagonist triprolidine did not (n=24). The excitatory effect of histamine could be mimicked by dimaprit, a highly selective H2 receptor agonist (n=24), and the dimaprit-elicited excitation of the rubral neurons could be blocked by ranitidine (n=16), but not by triprolidine (n=9). In addition, H1 receptor agonist 2-pyridylethylamine could not elicit any response in rubral neurons (n=12). These results indicate that histamine excites red nucleus neurons through H2 receptors and suggest that the histaminergic afferent fibers may play an important functional role in the sensorimotor integration through the red nucleus. |
| Databáze: | OpenAIRE |
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