Aortic stiffness and flow-mediated dilatation in normotensive offspring of parents with hypertension

Autor: Asuman Kaftan, Harun Evrengul, Halil Tanriverdi, Emin Evren Özcan, Dursun Dursunoglu, Mustafa Kilic, Ismail Dogu Kilic
Rok vydání: 2012
Předmět:
Male
Parents
Brachial Artery
brachial artery
Blood Pressure
artery compliance
Doppler echocardiography
endothelial function
Young adult
Brachial artery
Family history
family history
medicine.diagnostic_test
adult
article
risk assessment
General Medicine
vasodilatation
Echocardiography
Doppler
Vasodilation
arterial stiffness
female
medicine.anatomical_structure
risk factor
Hypertension
blood vessel parameters
Cardiology
Female
Aortic stiffness
Cardiology and Cardiovascular Medicine
cardiovascular risk
medicine.medical_specialty
hypertension
Adolescent
Endothelium
subclinical atherosclerosis
Offspring
progeny
Young Adult
Vascular Stiffness
male
medicine.artery
Internal medicine
flow mediated dilatation
medicine
Humans
controlled study
Genetic Predisposition to Disease
human
business.industry
high risk population
body mass
Blood pressure
age
Pediatrics
Perinatology and Child Health
Endothelium
Vascular
atherosclerosis
business
non-invasive indicators of atherosclerosis
Zdroj: Cardiology in the Young. 22:451-456
ISSN: 1467-1107
1047-9511
Popis: ObjectivesAlthough hypertension has been shown to be one of the most important risk factors for atherosclerosis, data about the presence of subclinical atherosclerosis in normotensive offspring with parental history of hypertension are scarce. Accordingly, the current study was designated to evaluate flow-mediated dilatation and aortic stiffness, which are early signs of atherosclerosis in young subjects with parental history of hypertension.MethodsA total of 102 healthy, non-obese subjects in the age group of 18–22 years were included in this study and divided into two groups. The first group included 70 offspring of hypertensive parents and the second group included 70 offspring of normotensive parents as controls. In all subjects, endothelium-dependent and endothelium-independent vasodilatation of the brachial artery and aortic elastic parameters were investigated using high-resolution Doppler echocardiography.ResultsOffspring of hypertensive parents demonstrated higher values of aortic stiffness (7.1 plus or minus 1.88 and 6.42 plus or minus 1.56, respectively) but lower distensibility (9.47 plus or minus 1.33 and 11.8 plus or minus 3.36 square centimetres per dyne per 106) and flow-mediated dilatation (4.57 plus or minus 1.3 versus 6.34 plus or minus 0.83 percent, p equals 0.0001, respectively) than offspring of hypertensive parents.ConclusionWe observed blunted endothelium-dependent dilatation and aortic stiffness in offspring of hypertensive parents compared with offspring of hypertensive parents. This is evident in the absence of overt hypertension and other diseases, suggesting that parental history of hypertension is a risk for subclinical atherosclerosis and it may contribute to the progression to hypertension and overt atherosclerosis in later life.
Databáze: OpenAIRE
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