Bacterial Diterpene Biosynthesis
| Autor: | Jeroen S. Dickschat |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diterpene biosynthesis
Alkyl and Aryl Transferases Bacteria 010405 organic chemistry Stereochemistry Bioactive molecules General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Stereocenter chemistry.chemical_compound chemistry Biosynthesis Diterpene Diterpenes |
| Zdroj: | Angewandte Chemie (International ed. in English). 58(45) |
| ISSN: | 1521-3773 |
| Popis: | This Minireview summarises recent developments in the biosynthesis of diterpenes by diterpene synthases in bacteria. It is structured by the class of enzyme involved in the first committed step towards diterpenes, starting with type I diterpene synthases, followed by type II enzymes and the more recently discovered UbiA-related diterpene synthases. A special emphasis lies on the reaction mechanisms of diterpene synthases that convert simple linear precursors through cationic cascades into structurally complex, usually polycyclic carbon skeletons with multiple stereogenic centres. A further main focus of this Minireview is a discussion of how these mechanisms can be unravelled. Downstream modifications to bioactive molecules are also covered. |
| Databáze: | OpenAIRE |
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