Differential regulation of metallothionein-I, II, and III mRNA expression in the rat brain following kainic acid treatment
| Autor: | Eun Hae Kim, Sun Hwa Park, Chang Sub Uhm, Changmee Kim, Hyun Jung Kim, Donghou Kim, Woong Sun, Hyun Kim |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Gene isoform medicine.medical_specialty Kainic acid Central nervous system Nerve Tissue Proteins Hippocampal formation Biology Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Piriform cortex Gene expression medicine Animals Protein Isoforms Metallothionein RNA Messenger In Situ Hybridization Neurons Kainic Acid General Neuroscience Brain Metallothionein 3 Rats Cell biology medicine.anatomical_structure Endocrinology Gene Expression Regulation nervous system chemistry Astrocytes Neuron |
| Zdroj: | NeuroReport. 14:679-682 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200304150-00004 |
| Popis: | Although metallothioneins (MTs) are believed to be involved in the protection against neural stresses, spatio-temporal regulation of MT isoforms following neural insults has not been thoroughly examined. In this study, we found that systemic application of kainic acid (KA) rapidly induced MT-I and II expression in neurons localized in hippocampal formation, piriform cortex, and amygdala of the adult rat, whereas the level of MT-III mRNA was decreased in KA-vulnerable areas. At 96 h after KA treatment, while the neuronal expression of MT-I and II returned to basal level, the glial expression of MT-I, II and III was increased in the reactive astrocytes. Differential regulation of MT isoforms in neuron and gila suggests that each isoform might have distinct role in the cell-type dependent cellular responses against KA-evoked neural injuries. |
| Databáze: | OpenAIRE |
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