MRI UTE-T2* profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction
| Autor: | Constance R. Chu, Ashley Williams, Thomas P. Andriacchi, Matthew R. Titchenal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Knee Joint Anterior cruciate ligament reconstruction medicine.medical_treatment Population Biomedical Engineering Walking Osteoarthritis Article Correlation 03 medical and health sciences 0302 clinical medicine Rheumatology medicine Humans Orthopedics and Sports Medicine In patient Patient Reported Outcome Measures education Gait 030203 arthritis & rheumatology 030222 orthopedics education.field_of_study Anterior Cruciate Ligament Reconstruction business.industry Anterior Cruciate Ligament Injuries Cartilage Mechanics medicine.disease Magnetic Resonance Imaging Biomechanical Phenomena medicine.anatomical_structure Gait analysis Female business Follow-Up Studies |
| Zdroj: | Osteoarthritis and Cartilage. 26:569-579 |
| ISSN: | 1063-4584 |
| Popis: | OBJECTIVE: Quantitative magnetic resonance imaging (MRI) ultrashort echo time (UTE) T2* is sensitive to cartilage deep tissue matrix changes after anterior cruciate ligament reconstruction (ACLR). This study was performed to determine whether UTE-T2* profile analysis is a useful clinical metric for assessing cartilage matrix degeneration. This work tests the hypotheses that UTE-T2* depthwise rates of change (profile slopes) correlate with clinical outcome metrics of walking mechanics and patient reported outcomes (PRO) in patients 2 years after ACLR. DESIGN: Thirty-six patients 2 years after ACLR completed knee MRI, gait analysis, and PRO. UTE-T2* maps were generated from MRI images and depthwise UTE-T2* profiles were calculated for weight-bearing cartilage in the medial compartment. UTE-T2* profiles from 14 uninjured subjects provided reference values. UTE-T2* profile characteristics, including several different measures of profile slope, were tested for correlation to kinetic and kinematic measures of gait and also to PRO. RESULTS: Decreasing UTE-T2* profile slopes in ACLR knees moderately correlated with increasing knee adduction moments (r = 0.41, P < 0.015), greater external tibial rotation (r = 0.44, P = 0.007), and moderately negatively correlated with PRO (r = −0.36, P = 0.032). UTE-T2* profiles from both ACLR and contralateral knees of ACLR subjects differed from that of uninjured controls (P < 0.015). CONCLUSIONS: The results of this study suggest that decreasing UTE-T2* profile slopes reflect cartilage deep tissue collagen matrix disruption in a population at increased risk for knee osteoarthritis (OA). That UTE-T2* profiles were associated with mechanical and patient reported measures of clinical outcomes support further study into a potential mechanistic relationship between these factors and OA development. |
| Databáze: | OpenAIRE |
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